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The phase III placebo-controlled trials of roflumilast evaluated the treatment in two 12-month (Lancet 2009; 374: 685?) and two six-month studies (Lancet 2009; 374: 695?), involving 4,500 patients in ten countries.
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It reduced exacerbations, or lung attacks, and significantly improved lung function, in a patient population whose lung function is very poor.
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